Androgen deprivation promotes intratumoral synthesis of dihydrotestosterone from androg... - 0 views
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prostate cancer 3-alpha androstanediol 3-beta androstanediol DHT metabolite metabolites
shared by Nathan Goodyear on 27 Jan 14
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PSA levels in media were increased by 3α-diol
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Similarly to 3α-diol, 3β-diol also increased PSA levels in media in a concentration-dependent manner
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intracellular DHT is synthesized from inactive androgen 3α- and 3β-diol via different pathways in prostate cancer cells
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serum 3α-diol G levels reflect the androgen milieu in localized prostate cancer patients receiving ADT
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A few studies reported that 3β-diol is a potential ligand of estrogen receptor β (ERβ) and has an antiproliferative effect
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Prostate cancer cells promoted synthesis from the DHT metabolite 3α-diol during the long duration of ADT
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verified the synthesis of DHT from 3α- or 3β-diol via different pathways in prostate cancer cells in this study
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HSD17B6 expression levels in prostate cancer can be useful for the diagnosis of high-risk prostate cancer
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DHT metabolites play an important role of intra-prostate DHT synthesis in those following ADT. This is a proposed mechanism for the failure rate and aggressive nature of prostate cancer that fails ADT. 3-alpha androstanediol is converted via 3 alpha HSD back to DHT. In contrast, 3-beta androstanediol cannot.